Pesquisa | Secretaria de Estado da Saúde

1.

Vaccine induction of CD4-mimicking HIV-1 broadly neutralizing antibody precursors in macaques.

Saunders, Kevin O; Counts, James; Thakur, Bhishem; Stalls, Victoria; Edwards, Robert; Manne, Kartik; Lu, Xiaozhi; Mansouri, Katayoun; Chen, Yue; Parks, Rob; Barr, Maggie; Sutherland, Laura; Bal, Joena; Havill, Nicholas; Chen, Haiyan; Machiele, Emily; Jamieson, Nolan; Hora, Bhavna; Kopp, Megan; Janowska, Katarzyna; Anasti, Kara; Jiang, Chuancang; Van Itallie, Elizabeth; Venkatayogi, Sravani; Eaton, Amanda; Henderson, Rory; Barbosa, Christopher; Alam, S Munir; Santra, Sampa; Weissman, Drew; Moody, M Anthony; Cain, Derek W; Tam, Ying K; Lewis, Mark; Williams, Wilton B; Wiehe, Kevin; Montefiori, David C; Acharya, Priyamvada; Haynes, Barton F.

Cell ; 187(1): 79-94.e24, 2024 01 04.

Artigo Inglês | MEDLINE | ID: mdl-38181743

2.

In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies.

Li, Dapeng; Edwards, Robert J; Manne, Kartik; Martinez, David R; Schäfer, Alexandra; Alam, S Munir; Wiehe, Kevin; Lu, Xiaozhi; Parks, Robert; Sutherland, Laura L; Oguin, Thomas H; McDanal, Charlene; Perez, Lautaro G; Mansouri, Katayoun; Gobeil, Sophie M C; Janowska, Katarzyna; Stalls, Victoria; Kopp, Megan; Cai, Fangping; Lee, Esther; Foulger, Andrew; Hernandez, Giovanna E; Sanzone, Aja; Tilahun, Kedamawit; Jiang, Chuancang; Tse, Longping V; Bock, Kevin W; Minai, Mahnaz; Nagata, Bianca M; Cronin, Kenneth; Gee-Lai, Victoria; Deyton, Margaret; Barr, Maggie; Von Holle, Tarra; Macintyre, Andrew N; Stover, Erica; Feldman, Jared; Hauser, Blake M; Caradonna, Timothy M; Scobey, Trevor D; Rountree, Wes; Wang, Yunfei; Moody, M Anthony; Cain, Derek W; DeMarco, C Todd; Denny, Thomas N; Woods, Christopher W; Petzold, Elizabeth W; Schmidt, Aaron G; Teng, I-Ting.

Cell ; 184(16): 4203-4219.e32, 2021 08 05.

Artigo Inglês | MEDLINE | ID: mdl-34242577

3.

Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.

Williams, Wilton B; Meyerhoff, R Ryan; Edwards, R J; Li, Hui; Manne, Kartik; Nicely, Nathan I; Henderson, Rory; Zhou, Ye; Janowska, Katarzyna; Mansouri, Katayoun; Gobeil, Sophie; Evangelous, Tyler; Hora, Bhavna; Berry, Madison; Abuahmad, A Yousef; Sprenz, Jordan; Deyton, Margaret; Stalls, Victoria; Kopp, Megan; Hsu, Allen L; Borgnia, Mario J; Stewart-Jones, Guillaume B E; Lee, Matthew S; Bronkema, Naomi; Moody, M Anthony; Wiehe, Kevin; Bradley, Todd; Alam, S Munir; Parks, Robert J; Foulger, Andrew; Oguin, Thomas; Sempowski, Gregory D; Bonsignori, Mattia; LaBranche, Celia C; Montefiori, David C; Seaman, Michael; Santra, Sampa; Perfect, John; Francica, Joseph R; Lynn, Geoffrey M; Aussedat, Baptiste; Walkowicz, William E; Laga, Richard; Kelsoe, Garnett; Saunders, Kevin O; Fera, Daniela; Kwong, Peter D; Seder, Robert A; Bartesaghi, Alberto; Shaw, George M.

Cell ; 184(11): 2955-2972.e25, 2021 05 27.

Artigo Inglês | MEDLINE | ID: mdl-34019795

4.

Pandemic Preparedness: Developing Vaccines and Therapeutic Antibodies For COVID-19.

Sempowski, Gregory D; Saunders, Kevin O; Acharya, Priyamvada; Wiehe, Kevin J; Haynes, Barton F.

Cell ; 181(7): 1458-1463, 2020 06 25.

Artigo Inglês | MEDLINE | ID: mdl-32492407

5.

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.

Bonsignori, Mattia; Zhou, Tongqing; Sheng, Zizhang; Chen, Lei; Gao, Feng; Joyce, M Gordon; Ozorowski, Gabriel; Chuang, Gwo-Yu; Schramm, Chaim A; Wiehe, Kevin; Alam, S Munir; Bradley, Todd; Gladden, Morgan A; Hwang, Kwan-Ki; Iyengar, Sheelah; Kumar, Amit; Lu, Xiaozhi; Luo, Kan; Mangiapani, Michael C; Parks, Robert J; Song, Hongshuo; Acharya, Priyamvada; Bailer, Robert T; Cao, Allen; Druz, Aliaksandr; Georgiev, Ivelin S; Kwon, Young D; Louder, Mark K; Zhang, Baoshan; Zheng, Anqi; Hill, Brenna J; Kong, Rui; Soto, Cinque; Mullikin, James C; Douek, Daniel C; Montefiori, David C; Moody, Michael A; Shaw, George M; Hahn, Beatrice H; Kelsoe, Garnett; Hraber, Peter T; Korber, Bette T; Boyd, Scott D; Fire, Andrew Z; Kepler, Thomas B; Shapiro, Lawrence; Ward, Andrew B; Mascola, John R; Liao, Hua-Xin; Kwong, Peter D.

Cell ; 165(2): 449-63, 2016 Apr 07.

Artigo Inglês | MEDLINE | ID: mdl-26949186

6.

Structural diversity of the SARS-CoV-2 Omicron spike.

Gobeil, Sophie M-C; Henderson, Rory; Stalls, Victoria; Janowska, Katarzyna; Huang, Xiao; May, Aaron; Speakman, Micah; Beaudoin, Esther; Manne, Kartik; Li, Dapeng; Parks, Rob; Barr, Maggie; Deyton, Margaret; Martin, Mitchell; Mansouri, Katayoun; Edwards, Robert J; Eaton, Amanda; Montefiori, David C; Sempowski, Gregory D; Saunders, Kevin O; Wiehe, Kevin; Williams, Wilton; Korber, Bette; Haynes, Barton F; Acharya, Priyamvada.

Mol Cell ; 82(11): 2050-2068.e6, 2022 06 02.

Artigo Inglês | MEDLINE | ID: mdl-35447081

7.

Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier.

Bonsignori, Mattia; Scott, Eric; Wiehe, Kevin; Easterhoff, David; Alam, S Munir; Hwang, Kwan-Ki; Cooper, Melissa; Xia, Shi-Mao; Zhang, Ruijun; Montefiori, David C; Henderson, Rory; Nie, Xiaoyan; Kelsoe, Garnett; Moody, M Anthony; Chen, Xuejun; Joyce, M Gordon; Kwong, Peter D; Connors, Mark; Mascola, John R; McGuire, Andrew T; Stamatatos, Leonidas; Medina-Ramírez, Max; Sanders, Rogier W; Saunders, Kevin O; Kepler, Thomas B; Haynes, Barton F.

Immunity ; 49(6): 1162-1174.e8, 2018 12 18.

Artigo Inglês | MEDLINE | ID: mdl-30552024

8.

Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.

Saunders, Kevin O; Lee, Esther; Parks, Robert; Martinez, David R; Li, Dapeng; Chen, Haiyan; Edwards, Robert J; Gobeil, Sophie; Barr, Maggie; Mansouri, Katayoun; Alam, S Munir; Sutherland, Laura L; Cai, Fangping; Sanzone, Aja M; Berry, Madison; Manne, Kartik; Bock, Kevin W; Minai, Mahnaz; Nagata, Bianca M; Kapingidza, Anyway B; Azoitei, Mihai; Tse, Longping V; Scobey, Trevor D; Spreng, Rachel L; Rountree, R Wes; DeMarco, C Todd; Denny, Thomas N; Woods, Christopher W; Petzold, Elizabeth W; Tang, Juanjie; Oguin, Thomas H; Sempowski, Gregory D; Gagne, Matthew; Douek, Daniel C; Tomai, Mark A; Fox, Christopher B; Seder, Robert; Wiehe, Kevin; Weissman, Drew; Pardi, Norbert; Golding, Hana; Khurana, Surender; Acharya, Priyamvada; Andersen, Hanne; Lewis, Mark G; Moore, Ian N; Montefiori, David C; Baric, Ralph S; Haynes, Barton F.

Nature ; 594(7864): 553-559, 2021 06.

Artigo Inglês | MEDLINE | ID: mdl-33971664

9.

A new class of antibodies that overcomes a steric barrier to cross-group neutralization of influenza viruses.

Simmons, Holly C; Watanabe, Akiko; Oguin Iii, Thomas H; Van Itallie, Elizabeth S; Wiehe, Kevin J; Sempowski, Gregory D; Kuraoka, Masayuki; Kelsoe, Garnett; McCarthy, Kevin R.

PLoS Biol ; 21(12): e3002415, 2023 Dec.

Artigo Inglês | MEDLINE | ID: mdl-38127922

10.

Identification of CDRH3 loops in the B cell receptor repertoire that can be engaged by candidate immunogens.

Swanson, Olivia; Martin Beem, Joshua S; Rhodes, Brianna; Wang, Avivah; Barr, Maggie; Chen, Haiyan; Parks, Robert; Saunders, Kevin O; Haynes, Barton F; Wiehe, Kevin; Azoitei, Mihai L.

PLoS Pathog ; 19(5): e1011401, 2023 05.

Artigo Inglês | MEDLINE | ID: mdl-37196027

11.

A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus.

Jenks, Jennifer A; Amin, Sharmi; Sponholtz, Madeline R; Kumar, Amit; Wrapp, Daniel; Venkatayogi, Sravani; Tu, Joshua J; Karthigeyan, Krithika; Valencia, Sarah M; Connors, Megan; Harnois, Melissa J; Hora, Bhavna; Rochat, Eric; McLellan, Jason S; Wiehe, Kevin; Permar, Sallie R.

PLoS Pathog ; 19(1): e1011107, 2023 01.

Artigo Inglês | MEDLINE | ID: mdl-36662906

12.

ARMADiLLO: a web server for analyzing antibody mutation probabilities.

Martin Beem, Joshua S; Venkatayogi, Sravani; Haynes, Barton F; Wiehe, Kevin.

Nucleic Acids Res ; 51(W1): W51-W56, 2023 07 05.

Artigo Inglês | MEDLINE | ID: mdl-37260077

13.

Host immunity associated with spontaneous suppression of viremia in therapy-naïve young rhesus macaques following neonatal SHIV infection.

Evangelous, Tyler D; Berry, Madison; Venkatayogi, Sravani; LeMaster, Cas; Geanes, Eric S; De Naeyer, Nicole; DeMarco, Todd; Shen, Xiaoying; Li, Hui; Hora, Bhavna; Solomonis, Nicholas; Misamore, Johnathan; Lewis, Mark G; Denny, Thomas N; Montefiori, David; Shaw, George M; Wiehe, Kevin; Bradley, Todd; Williams, Wilton B.

J Virol ; 97(11): e0109423, 2023 Nov 30.

Artigo Inglês | MEDLINE | ID: mdl-37874153

14.

Complementary Roles of Antibody Heavy and Light Chain Somatic Hypermutation in Conferring Breadth and Potency to the HIV-1-Specific CAP256-VRC26 bNAb Lineage.

Sacks, David; Wiehe, Kevin; Morris, Lynn; Moore, Penny L.

J Virol ; 96(10): e0027022, 2022 05 25.

Artigo Inglês | MEDLINE | ID: mdl-35510865

15.

Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates.

Cai, Fangping; Chen, Wei-Hung; Wu, Weimin; Jones, Julia A; Choe, Misook; Gohain, Neelakshi; Shen, Xiaoying; LaBranche, Celia; Eaton, Amanda; Sutherland, Laura; Lee, Esther M; Hernandez, Giovanna E; Wu, Nelson R; Scearce, Richard; Seaman, Michael S; Moody, M Anthony; Santra, Sampa; Wiehe, Kevin; Tomaras, Georgia D; Wagh, Kshitij; Korber, Bette; Bonsignori, Mattia; Montefiori, David C; Haynes, Barton F; de Val, Natalia; Joyce, M Gordon; Saunders, Kevin O.

PLoS Pathog ; 17(6): e1009624, 2021 06.

Artigo Inglês | MEDLINE | ID: mdl-34086838

16.

Antibody light-chain-restricted recognition of the site of immune pressure in the RV144 HIV-1 vaccine trial is phylogenetically conserved.

Wiehe, Kevin; Easterhoff, David; Luo, Kan; Nicely, Nathan I; Bradley, Todd; Jaeger, Frederick H; Dennison, S Moses; Zhang, Ruijun; Lloyd, Krissey E; Stolarchuk, Christina; Parks, Robert; Sutherland, Laura L; Scearce, Richard M; Morris, Lynn; Kaewkungwal, Jaranit; Nitayaphan, Sorachai; Pitisuttithum, Punnee; Rerks-Ngarm, Supachai; Sinangil, Faruk; Phogat, Sanjay; Michael, Nelson L; Kim, Jerome H; Kelsoe, Garnett; Montefiori, David C; Tomaras, Georgia D; Bonsignori, Mattia; Santra, Sampa; Kepler, Thomas B; Alam, S Munir; Moody, M Anthony; Liao, Hua-Xin; Haynes, Barton F.

Immunity ; 41(6): 909-18, 2014 Dec 18.

Artigo Inglês | MEDLINE | ID: mdl-25526306

17.

Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2.

Liao, Hua-Xin; Bonsignori, Mattia; Alam, S Munir; McLellan, Jason S; Tomaras, Georgia D; Moody, M Anthony; Kozink, Daniel M; Hwang, Kwan-Ki; Chen, Xi; Tsao, Chun-Yen; Liu, Pinghuang; Lu, Xiaozhi; Parks, Robert J; Montefiori, David C; Ferrari, Guido; Pollara, Justin; Rao, Mangala; Peachman, Kristina K; Santra, Sampa; Letvin, Norman L; Karasavvas, Nicos; Yang, Zhi-Yong; Dai, Kaifan; Pancera, Marie; Gorman, Jason; Wiehe, Kevin; Nicely, Nathan I; Rerks-Ngarm, Supachai; Nitayaphan, Sorachai; Kaewkungwal, Jaranit; Pitisuttithum, Punnee; Tartaglia, James; Sinangil, Faruk; Kim, Jerome H; Michael, Nelson L; Kepler, Thomas B; Kwong, Peter D; Mascola, John R; Nabel, Gary J; Pinter, Abraham; Zolla-Pazner, Susan; Haynes, Barton F.

Immunity ; 38(1): 176-86, 2013 Jan 24.

Artigo Inglês | MEDLINE | ID: mdl-23313589

18.

Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency.

Easterhoff, David; Pollara, Justin; Luo, Kan; Tolbert, William D; Young, Brianna; Mielke, Dieter; Jha, Shalini; O'Connell, Robert J; Vasan, Sandhya; Kim, Jerome; Michael, Nelson L; Excler, Jean-Louis; Robb, Merlin L; Rerks-Ngarm, Supachai; Kaewkungwal, Jaranit; Pitisuttithum, Punnee; Nitayaphan, Sorachai; Sinangil, Faruk; Tartaglia, James; Phogat, Sanjay; Kepler, Thomas B; Alam, S Munir; Wiehe, Kevin; Saunders, Kevin O; Montefiori, David C; Tomaras, Georgia D; Moody, M Anthony; Pazgier, Marzena; Haynes, Barton F; Ferrari, Guido.

J Virol ; 94(4)2020 01 31.

Artigo Inglês | MEDLINE | ID: mdl-31776278

19.

Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage.

Sacks, David; Bhiman, Jinal N; Wiehe, Kevin; Gorman, Jason; Kwong, Peter D; Morris, Lynn; Moore, Penny L.

PLoS Pathog ; 15(9): e1008005, 2019 09.

Artigo Inglês | MEDLINE | ID: mdl-31479499

20.

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.

LaBranche, Celia C; Henderson, Rory; Hsu, Allen; Behrens, Shay; Chen, Xuejun; Zhou, Tongqing; Wiehe, Kevin; Saunders, Kevin O; Alam, S Munir; Bonsignori, Mattia; Borgnia, Mario J; Sattentau, Quentin J; Eaton, Amanda; Greene, Kelli; Gao, Hongmei; Liao, Hua-Xin; Williams, Wilton B; Peacock, James; Tang, Haili; Perez, Lautaro G; Edwards, Robert J; Kepler, Thomas B; Korber, Bette T; Kwong, Peter D; Mascola, John R; Acharya, Priyamvada; Haynes, Barton F; Montefiori, David C.

PLoS Pathog ; 15(9): e1008026, 2019 09.

Artigo Inglês | MEDLINE | ID: mdl-31527908

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